منابع مشابه
Complement Activation
The complement system is the most important biochemical cascade in the blood for the recognition, opsonization, and elimination of foreign materials. To date, the leading causes of death in the United States include cancer, cardiovascular and neurodegenerative diseases, and diabetes. New treatments are urgently needed to treat these devastating diseases and nanotechnology potentially provides n...
متن کاملNanoporesize affects complement activation.
In the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system. The study was done using nanoporous aluminiumoxide, a material that previously has...
متن کاملActivation of Complement
Activation of the complement system by IgA has been a controversial subject since Ishizaka et al. (1) and South et al. (2) observed that C1 was not fixed by IgA. Lack of complement activation has also been inferred from reports that secretory IgA antibodies were unable to opsonize or promote bacterial killing in the presence of complement (3 6). On the other hand, there is evidence that some co...
متن کاملComplement activation in uveitis.
To determine whether complement is activated in uveitis we have measured plasma levels of C3d, a sensitive indicator of complement activation. Increased levels of C3d were found in 11 of 15 patients with idiopathic uveitis, 13 of whom had circulating immune complexes containing complement components. Since during complement activation potent mediators of inflammation are generated, it is sugges...
متن کاملComplement monitoring of carbon nanotubes.
To the Editor — In their survey describing the promises and challenges of carbon nanotubes in imaging and therapeutics, Kostarelos and colleagues1 state that “...chemically functionalized [carbon] nanotubes have been shown by many groups to be more biocompatible (no immune or acute inflammatory responses) than pristine nanotubes.” We point out below in vitro and in vivo studies that show surfac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2019
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.12111019